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ALA inhibits Th17 cell promotion, through decreased ICAM-1expression in both ob-ASC and monocytes

The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance

  • NAD+-boosting agent nicotinamide riboside (NR) reduces mitochondrial activity within HSCs through increased mitochondrial clearance,
    • leading to increased asymmetric HSC divisions.
  • NR dietary supplementation results in a significantly enlarged pool of progenitors, without concurrent HSC exhaustion, improves survival by 80%,
  • and accelerates blood recovery after murine lethal irradiation and limiting-HSC transplantation

Insulin receptor isoform A favors tumor progression in human hepatocellular carcinoma by increasing stem/progenitor cell features.

  • Hepatocellular carcinoma (HCC) is one of the most common and deadly neoplasms. Insulin receptor (IR) exists in two isoforms, IR-A and IR-B, the latter being predominantly expressed in normal adult hepatocytes while IR-A is overexpressed in HCC to the detriment of IR-B .... IR-A overexpression promoted gene programs related to stemness, inflammation and cell movement
    • cancer cells express outcompeting insulin receptors, seemingly causing a preferential (over normal cells) uptake of glucose. Good reason to burn fat.

Serum and nutrient deprivation increase autophagic flux in intervertebral disc annulus fibrosus cells: an in vitro experimental study.

  • Expectable that nutrition deficiencies will lead to systemmic reduced proliferation and metabolic activity, probably leading to shorter stature

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