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Vitamin D

  • Cell need variance is not adequately accounted for by oral ingestion; whereas, from the sun, skin cells will get the most vitamin D and probably need the most, with oral ingestion, intestinal cells will get the most vitamin D and probably need the least.

APOE 4

  • High cholesterol as needed for greater Vitamin D creation from otherwise inadequate sun intensity from northern climate

Fats

[1903-fats]

Eicosanoids (prostaglandins, …) are variably balanced on diet based on genetics. Some people, disposed, ancestrally, towards eating fish, will probably have relative underactive D6D (since the need for transitioning plant fats wasn’t necessary) and a disposition for higher series 2 activity (since there was relatively little arachidonic acid in the diet, it was necessary to be hyper-responsive to it), presenting the scenario wherein modern diets of high arachidonic acid (land animals) and low EPA and DHA (fish) will lead to an overactivity, and lack of mitigation, of series 2 prostaglandins. Depending on D6D activity, this situation can be rectified by {either ALA (adequate D6D activity) or consumption of DHA and EPA} and consumption of oleic acid (monounsaturated) to decrease series 2 activity.

[1902-fats]

Some fats induce higher amounts of fat metabolism

n-3 polyunsaturated fatty acids provoke a specific transcriptional profile in rabbit adipose-derived stem cells in vitro.
The data obtained in our study indicate that in vitro EPA up-regulates the mRNA expression of the studied lipolysis-associated genes stronger than DHA mainly in visceral rabbit ADSCs.

Diabetes

[1806-diabetes]

Diabetes is, in part, an insulin metabolism issue, with a particular disruptive compound formed in the absense of a particular nutrient (and this disruptive compound was discovered in the 60s)

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