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Studies indicate over some dosage there is an increased rate of mortality
But, this is true for most antioxidants
My thought is that this is a consequence of disbalance in the antioxidant network. If you have too much vitamin E being oxidized and not enough vitamin C or glutathione to cycle the vitamin E, then vitamin E becomes a pro-oxidant (probably by the nature of it being very mobile).
Why would vitamin E be associated with increased prostate cancer? Probably b/c one of the ways in which cancer cells die is by oxidation of their lipid membranes as a consequence of the cells rapid rate of metabolism through glycolysis, and in that vitamin E protects the membrane from this oxidation, the cancer cell membrane does not encounter enough oxidation to go through apoptosis or through necrosis.